abstract：:Objective: We compare estimates of proportion of days covered (PDC) based on dispensation-only data versus linked prescription and dispensation information, and we analyse their differences in a real-world cohort of patients with osteoporosis.Methods: Prospective cohort study. We compared four alternative measures of ...

journal_title：Current medical research and opinion

authors： García-Sempere A,Hurtado I,Sanfélix-Genovés J,Rodríguez-Bernal C,Peiró S,Sanfélix-Gimeno G

更新日期：2019-09-01 00:00:00

abstract：:Objective: A prior study found that hyaluronic acid (HA) treatment may help reduce pain medication use (such as steroids, non-steroidal anti-inflammatory drugs [NSAIDs] and opioids) among knee osteoarthritis (OA) patients in the real-world setting. This study aims to update the prior study results to include only the ...

journal_title：Current medical research and opinion

authors： Chitnis AS,Etter K,Holy CE,Gray FS,Manalac FJ,Bisson B,Bhattacharyya SK

更新日期：2019-09-01 00:00:00

abstract：:Objective: To assess real-world costs for patients with hemophilia A treated with bypassing agents versus factor VIII (FVIII) replacement. Methods: Claims data from a large US health insurer during 1 January 2006-30 September 2014 were used for analysis. Treated patients with hemophilia A were identified based on ≥1 m...

journal_title：Current medical research and opinion

authors： Swindle JP,Xu Y,Mu Y,Solari PG

更新日期：2019-08-01 00:00:00

abstract：:Objectives: Asthma/chronic obstructive pulmonary disease (COPD) overlap (ACO) is a recently described phenomenon defined as the coexistence of both asthma and COPD. Both asthma and COPD are known to result in increased emergency department (ED) visits and hospitalizations, but it is unclear how the ACO population util...

journal_title：Current medical research and opinion

authors： Kim M,Tillis W,Patel P,Davis RM,Asche CV

更新日期：2019-07-01 00:00:00

abstract：:Normalizing serum thyroid stimulating hormone (TSH) levels by lifelong treatment with levothyroxine (LT4) remains the primary goal of therapy for patients with hypothyroidism. The reference ranges for TSH are derived from populations with (supposedly) normal thyroid function. But, TSH results are affected by a number ...

journal_title：Current medical research and opinion

authors： Razvi S,Hostalek U

更新日期：2019-07-01 00:00:00

abstract：:Objectives: Atopic dermatitis (AD) is a chronic, relapsing skin condition, with signs and symptoms that impact patients' lives and are best measured from the patient perspective. Therefore, there is a need for AD-specific questionnaires that are consistent with Food and Drug Administration guidance and best measuremen...

journal_title：Current medical research and opinion

authors： Foley C,Tundia N,Simpson E,Teixeira HD,Litcher-Kelly L,Bodhani A

更新日期：2019-07-01 00:00:00

abstract：:Adherence to allergen immunotherapy (AIT) is crucial for its efficacy. Subcutaneous AIT requires monthly visits (or more extended in the case of venom immunotherapy), while sublingual AIT is performed with a daily intake of allergen drops. Non-adherence to an AIT schedule and premature discontinuation are common probl...

journal_title：Current medical research and opinion

authors： Pitsios C,Dietis N

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVES:Data related to the cost effectiveness of surgical interventions and catheter ablation is sparse. This model-based analysis assessed the clinical and economic trade-offs involved in using catheter ablation or the Cox maze procedure in treating patients with atrial fibrillation. METHODS:A deterministic model...

journal_title：Current medical research and opinion

authors： Yang YT,Ortendahl J

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:In May 2018, the US Food and Drug Administration approved pegvaliase-pqpz (Palynziq*), the first enzyme substitution therapy for the treatment of phenylketonuria (PKU). This article provides an overview of the mechanism of action, pharmacokinetic properties, clinical efficacy, and the safety and tolerability ...

journal_title：Current medical research and opinion

authors： Mahan KC,Gandhi MA,Anand S

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVE:Postpartum depression (PPD) is the most common medical complication of childbirth. PPD can be disabling, with potential negative effects on maternal health-related quality-of-life (HRQoL) as well as on children and partners. The objective of this study was to systematically review and summarize recently publi...

journal_title：Current medical research and opinion

authors： Moore Simas TA,Huang MY,Patton C,Reinhart M,Chawla AJ,Clemson C,Eldar-Lissai A

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:Acute postprandial hyperglycemia (aPPHG) is often symptomatic and can be associated with behavioral changes such as impaired working memory and attention. However, there is little evidence of the impact of aPPHG on the daily lives of patients. The aim of this study was to explore the frequency and severity of...

journal_title：Current medical research and opinion

authors： Heller S,Meneghini L,Nikolajsen A,Kragh N,Lewis HB,Saretsky T,Kosmas CE,Lloyd A

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:We evaluated the clinical efficacy of sacubitril/valsartan in a group of ambulatory patients with heart failure (HF) with reduced ejection fraction (HFrEF) referred to our HF clinic. METHODS:Patients (n = 29; 72% males; mean age 76 years) with HFrEF in New York Heart Association (NYHA) classes II-III were in...

journal_title：Current medical research and opinion

authors： Cosentino ER,Degli Esposti D,Miceli R,Bentivenga C,Landolfo M,Fg Cicero A,Berardi E,Spinardi L,Magri G,Dugato V,Borghi C

更新日期：2019-03-01 00:00:00

abstract：:Liver transplantation is currently a standard therapy for patients with end-stage liver diseases and hepatocellular carcinoma. Given that liver transplantation has undergone a thriving development in these decades, the survival rates after liver transplantation have markedly improved as a result of the critical advanc...

journal_title：Current medical research and opinion

authors： Mu J,Chen Q,Zhu L,Wu Y,Liu S,Zhao Y,Ma T

更新日期：2019-02-01 00:00:00

abstract：:Objective: To evaluate the risk of chronic kidney disease (CKD), cardiovascular disease (CVD), and osteoporotic fractures in human immunodeficiency virus (HIV) patients utilizing data within the Veteran's Affairs (VA) Administration system.Methods: A retrospective cohort study utilizing VA system claims (January 2000-...

journal_title：Current medical research and opinion

authors： Sutton SS,Magagnoli J,Cummings TH,Hardin JW,Edun B,Beaubrun A

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:To analyze the effect of brexpiprazole on metabolic parameters and body weight in adults with schizophrenia, including clinically relevant sub-groups of patients, based on data from two pivotal phase 3 studies (NCT01393613; NCT01396421) and a long-term extension study (NCT01397786). METHODS:The short-term st...

journal_title：Current medical research and opinion

authors： Newcomer JW,Eriksson H,Zhang P,Weiller E,Weiss C

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:To evaluate four models based on potential predictors for achieving a response to pregabalin treatment for neuropathic pain (NeP). METHODS:In total, 46 pain studies were screened, of which 27 NeP studies met the criteria for inclusion in this analysis. Data were pooled from these 27 placebo-controlled random...

journal_title：Current medical research and opinion

authors： Almas M,Parsons B,Whalen E

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Atrial fibrillation (AF) is the most common arrhythmia in clinical practice and is associated with increased cardiovascular morbidity and mortality. Epicardial adipose tissue (EAT) serves as a biologically active organ with important endocrine and inflammatory function. Review An accumulating body of evidenc...

journal_title：Current medical research and opinion

authors： Goudis CA,Vasileiadis IE,Liu T

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:To compare real-world adherence to and persistence with deferasirox film-coated tablets (DFX-FCT) and deferasirox dispersible tablets (DFX-DT) among patients who switched from DFX-DT to DFX-FCT, overall and by disease type (sickle cell disease [SCD], thalassemia, and myelodysplastic syndrome [MDS]). METHODS:...

journal_title：Current medical research and opinion

authors： Cheng WY,Said Q,Hao Y,Xiao Y,Vekeman F,Bobbili P,Duh MS,Nandal S,Blinder M

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Rheumatoid arthritis (RA) is a chronic, debilitating disease affecting an estimated 1.5 million patients in the US. The condition is associated with a substantial health and economic burden. An economic model was developed to evaluate the cost-effectiveness of tofacitinib (a novel oral Janus k...

journal_title：Current medical research and opinion

authors： Claxton L,Taylor M,Gerber RA,Gruben D,Moynagh D,Singh A,Wallenstein GV

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVE:In the four SMILE (Survival of Myocardial Infarction Long-Term Evaluation) studies, early administration of zofenopril in acute myocardial infarction (AMI) showed beneficial effects as compared to placebo and other angiotensin converting enzyme inhibitors (ACEIs). This study investigated whether the concomita...

journal_title：Current medical research and opinion

authors： Borghi C,Omboni S,Reggiardo G,Bacchelli S,Degli Esposti D,Ambrosioni E,SMILE (Survival of Myocardial Infarction Long-Term Evaluation) Working Project.

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:This retrospective study assessed the incidence and timing of adverse events (AEs) among patients prescribed varying dose levels of corticosteroids in the US. METHODS:Patients with selected autoimmune or inflammatory disease diagnoses between 2006 and 2015 were identified from a privately insured administrat...

journal_title：Current medical research and opinion

authors： Rice JB,White AG,Johnson M,Wagh A,Qin Y,Bartels-Peculis L,Ciepielewska G,Nelson WW

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:Based on the clear neuroanatomical delineation of many neuropathic pain (NP) symptoms, a simple tool for performing a short structured clinical encounter based on the IASP diagnostic criteria was developed to identify NP. This study evaluated its accuracy and usefulness. METHODS:A case-control study was perf...

journal_title：Current medical research and opinion

authors： Mayoral V,Pérez-Hernández C,Muro I,Leal A,Villoria J,Esquivias A

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:The impact of multiple sclerosis (MS) center type on outcomes has not been investigated. This study aimed to evaluate baseline characteristics and clinical and magnetic resonance imaging (MRI) outcomes in patients with MS receiving fingolimod over 16 months' follow-up at private or academic centers in the USA...

journal_title：Current medical research and opinion

authors： Zivadinov R,Khan N,Korn JR,Lathi E,Silversteen J,Calkwood J,Kolodny S,Silva D,Medin J,Weinstock-Guttman B,MS-MRIUS study group.

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:To describe a post hoc analysis comparing the effect of a hyaluronic acid (HA)-trehalose solution to an established eyedrop solution containing HA alone using Ocular Surface Disease Index (OSDI) score <19 as a threshold for moderate to severe dry eye disease (DED). METHODS:A phase III, randomized, controlled...

journal_title：Current medical research and opinion

authors： Doan S,Bremond-Gignac D,Chiambaretta F

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:In patch-based transdermal drug delivery, adhesiveness is critical for safe and effective treatment, especially in Parkinson's disease (PD) where excessive sweating is common. This study compared the adhesiveness of two transdermal patch formulations of rotigotine (improved room temperature-stable [PR2.3.1/Tr...

journal_title：Current medical research and opinion

authors： Elshoff JP,Bauer L,Goldammer N,Oortgiesen M,Pesch H,Timmermann L

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Calcipotriol 50 µg/g and betamethasone 0.5 mg/g dipropionate (Cal/BD) aerosol foam formulation provides greater effectiveness and improved patient preference compared with traditional Cal/BD formulations for the topical treatment of plaque psoriasis. OBJECTIVE:To determine the cost-effectiveness of Cal/BD f...

journal_title：Current medical research and opinion

authors： Foley P,Garrett S,Ryttig L

更新日期：2018-07-01 00:00:00

abstract：:Objective To assess the efficacy of a mixed intervention, educational, and reminder calendar of the intake, as a strategy to improve therapeutic adherence with dabigatran in patients with non-valvular atrial fibrillation (NVAF). Methods This was a prospective, longitudinal, multi-center study, carried out in 110 speci...

journal_title：Current medical research and opinion

authors： Márquez-Contreras E,Martell-Claros N,Márquez-Rivero S,Hermida-Campa E,Gracia-Diez C,Sanchez-López E,Gil-Guillén V,Compliance and Inertia Working Group, Spanish Society of Hypertension (SEH-LELHA).

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:To estimate the proportion of patients with moderate to severe chronic kidney disease (CKD) whose initial dipeptidyl-peptidase-4 inhibitor (DPP4-i) dosage was concordant with prescribing information (label) recommendations in the United States. METHODS:Adult patients with type 2 diabetes mellitus (T2DM) who ...

journal_title：Current medical research and opinion

authors： Huang H,Shetty S,Bauer E,Lang K

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:To compare the effectiveness of 20:1 cafedrine/theodrenaline approved for use in Germany to ephedrine in the restoration of arterial blood pressure and on post-operative outcomes in patients with intra-operative arterial hypotension of any origin under standard clinical practice conditions. METHODS AND RESUL...

journal_title：Current medical research and opinion

authors： Eberhart L,Geldner G,Huljic S,Marggraf K,Keller T,Koch T,Kranke P

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:To look into current evidence exploring the added value of rLH supplementation to rFSH in GnRH analogues cycles, to identify groups of women that still have no evidence for adjuvant rLH therapy and to discuss ways that may advance research on this topic. METHODS:Eight systematic reviews and meta-analyses exp...

journal_title：Current medical research and opinion

authors： Younis JS,Laufer N

更新日期：2018-05-01 00:00:00

abstract：AIM:The aim of this case series was to report the use of 8% topical capsaicin patch (marketed under the trade name Qutenza®) a in the management of refractory neuropathic pain (NP) in adult patients with type 1 neurofibromatosis (NF1). METHODS:Capsaicin has been suggested for NF1 patients suffering from refractory per...

journal_title：Current medical research and opinion

authors： Bardo-Brouard P,Luizard C,Valeyrie-Allanore L,Goujon C,Do B,Colin A,Wolkenstein P,Paul M

更新日期：2018-05-01 00:00:00

abstract：INTRODUCTION:Detection of β-thalassemia trait or carriers (β-TT) depends significantly on an increase in Hemoglobin A2 (HbA2) levels, which is found at low levels (<3%) in normal healthy individuals and elevated levels (≥3.5%) in β-TT individuals. The study was designed to evaluate the reliability of the diagnostic par...

journal_title：Current medical research and opinion

authors： Al-Amodi AM,Ghanem NZ,Aldakeel SA,Ibrahim Al Asoom L,Rafique Ahmed N,Almandil NB,Naserullah ZA,Al-Jarrash S,Shakil Akhtar M,AbdulAzeez S,Al-Ali AK,Borgio JF

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVES:We conducted an adjusted comparison of progression-free survival (PFS) and overall survival (OS) for daratumumab monotherapy versus standard of care, as observed in a real-world historical cohort of heavily pretreated multiple myeloma patients from Czech Republic. METHODS:Using longitudinal chart data from ...

journal_title：Current medical research and opinion

authors： Jelínek T,Maisnar V,Pour L,Špička I,Minařík J,Gregora E,Kessler P,Sýkora M,Fraňková H,Adamová D,Wróbel M,Mikula P,Jarkovský J,Diels J,Gatopoulou X,Veselá Š,Besson H,Brožová L,Ito T,Hájek R

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVE:Schizophrenia is one of the most debilitating diseases in the United Arab Emirates. Oral antipsychotics (OA) are commonly used in terms of pharmacotherapy; however, these treatments can be rendered ineffective by poor patient adherence. Paliperidone palmitate once monthly (PP1M) is a long acting antipsychotic...

journal_title：Current medical research and opinion

authors： Nuhoho S,Saad A,Saumell G,Ribes D,El Khoury AC

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:Abuse and misuse of prescription opioids is a significant public health concern. This review examines the strategies used to confer abuse-deterrent properties on opioid abuse-deterrent formulations (ADFs), the characteristics and supporting data for each of the available ADFs, and the role of opioid ADFs as p...

journal_title：Current medical research and opinion

authors： Pergolizzi JV Jr,Raffa RB,Taylor R Jr,Vacalis S

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVES:To compare 1-year direct healthcare costs and utilization among children and adolescents initiating non-stimulant medications atomoxetine (ATX) or extended-release guanfacine (GXR). METHODS:In this retrospective, observational cohort study, children and adolescents aged 6-17 years with attention deficit/hyp...

journal_title：Current medical research and opinion

authors： Molife C,Haynes VS,Nyhuis A,Faries DE,Gelwicks S,Kelsey DK,Alatorre CI

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:To evaluate inpatient oral anticoagulant (OAC) treatment, discharge location, and post-discharge OAC treatment for patients hospitalized with non-valvular atrial fibrillation (NVAF). RESEARCH DESIGN AND METHODS:Retrospective study using claims data linked to hospital electronic health records (EHR). Patients...

journal_title：Current medical research and opinion

authors： Henk HJ,Cao F,Tuell K,Price K,Singh P,Mardekian J,Odell K,Patel C,Tan W,Sands GH,Singhal S,Trocio J,Vo L

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:It has been postulated that intraocular pressure, an important glaucoma risk factor, correlates positively with arterial blood pressure (blood pressure). However, results of experimental and clinical studies are often contradictory. It is hypothesized that, in some hypertensive patients, disturbances in intr...

journal_title：Current medical research and opinion

authors： Skrzypecki J,Grabska-Liberek I,Przybek J,Ufnal M

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Obstructive sleep apnea syndrome (OSAS) is mostly seen in adult populations. It is known that increased levels of several inflammatory mediators play roles in OSAS and related comorbidities. Calprotectin is an inflammatory mediator that increases in some diseases such as Behçet's syndrome, bowel diseases and...

journal_title：Current medical research and opinion

authors： Torun MT,Ünver E,Yalçın Y,Kanmaz L,Seçkin E

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVES:Due to the high cost of nonvalvular atrial fibrillation (NVAF), this condition may be a suitable candidate for condition-specific bundled payments. This paper evaluates the healthcare cost of NVAF and uses common bleeding and stroke risk scores (HAS-BLED and CHA2DS2-VASc) to explore the risk-based healthcare...

journal_title：Current medical research and opinion

authors： Kaatz S,Coleman CI,Bookhart B,Laliberté F,Nelson WW,Brown K,Martin S,Schein J,Lefebvre P

更新日期：2018-02-01 00:00:00